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New Zealands experience suggests that harm reduction may have accelerated the decline of smoking and delivered benefits to populations that have historically carried the greatest burden of tobacco-related disease

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"We believe states and localities should defer to this process and allow Congress the opportunity to think through this issue further before enacting different minimum-age laws." Thomas Glynn, who reviewed the report for the Institute of Medicine, called the report a "monument to good science" and a "contribution to the health of every citizen in the U.S." Glynn, a consulting professor at the Stanford Prevention Research Center at Stanford University's School of Medicine, says he was initially skeptical of the idea of raising the legal age to buy tobacco to 21

Nicotine can influence the cholinergic anti-inflammatory pathway and nicotinic acetylcholine receptors, which are connected to vagal signaling